Tumor progressiontargets for differential therapy

AB Pardee - Journal of cellular physiology, 2006 - Wiley Online Library
Differential killing of the patient's cancer cells versus normal cells is a necessity for
chemotherapy. Advantage can be taken of close regulations of gene expression and of enzyme …

[HTML][HTML] The Mitochondrial ATP Synthase/IF1 Axis in Cancer Progression: Targets for Therapeutic Intervention

S Domínguez-Zorita, JM Cuezva - Cancers, 2023 - mdpi.com
… whereas OXPHOS prevails in differentiated cells [180,181]. Interestingly, IF1 also plays a
relevant role in metabolic reprogramming during differentiation of human mesenchymal stem …

Molecular alterations associated with bladder cancer progression

M Sánchez-Carbayo, C Cordon-Cardó - Seminars in oncology, 2007 - Elsevier
… will have one or more recurrences after initial treatment, and … squamous differentiation,
histopathological stage, and tumor … can serve to validate progression targets identified using DNA …

Modeling the cancer stem cell hypothesis

C Calmelet, A Prokop, J Mensah… - … Modelling of Natural …, 2010 - cambridge.org
… the differentiated tumors are less responsive to therapy compared to rapidly proliferating
partially differentiated tumors… The employment of mathematics allows us to target therapy to any …

Molecular markers of aggressiveness of thyroid cancer

MD Ringel - Current Opinion in Endocrinology, Diabetes and …, 2009 - journals.lww.com
… aggressive course in PTC is the high rate (>70%) of BRAF mutations in tumor tissue of
patients enrolled in a recent clinical trial for treatment-resistant differentiated thyroid cancer [18•] . …

EGFR, HER2 and VEGF pathways: validated targets for cancer treatment

MF Press, HJ Lenz - Drugs, 2007 - Springer
… in tumour growth, progression or survival. Several targeted therapies with anti-tumour activity
in human cancer … to produce objective responses, delay disease progression and, in some …

[HTML][HTML] MicroRNAs are involved in cervical cancer development, progression, clinical outcome and improvement treatment response

V González-Quintana, L Palma-Berré… - Oncology …, 2016 - spandidos-publications.com
… -positive patients and in less-differentiated tumors (31). Kaplan-… As therapeutic agents,
miRNAs were employed to enhance … damage repair and cell cycle progression targets (41–43). …

Identifying oxidative stress-related biomarkers in idiopathic pulmonary fibrosis in the context of predictive, preventive, and personalized medicine using integrative …

F Yang, Wendusubilige, J Kong, Y Zong, M Wang… - EPMA Journal, 2023 - Springer
… patients who were sensitive to antioxidant therapy to conduct differential gene functional
enrichment analysis and predict potential therapeutic drugs. Diagnostic markers between …

ERα inhibits mesenchymal and amoeboidal movement of liver cancer cell via Gα12

J Yun, YS Kim, MJ Heo, MJ Kim… - … Journal of Cancer, 2022 - Wiley Online Library
… , and consequent better survival rates observed in females, supporting the idea that modulating
the ERα-Gα12 pathway may be utilized for sex differential approaches in HCC treatment. …

Diagnostics and Therapeutic Potential of miR-205 and miR-34a in Ovarian Cancer Management: A miRNA-Target-Based Analysis

V Kumar, A Pandey, A Arora, P Gautam… - DNA and Cell …, 2023 - liebertpub.com
… can only be provided when the incidence of the disease is diagnosed in the early stages, …
disease progression since they are involved in essential processes such as cell differentiation, …